Lysophospholipid Receptors: Signaling and Biochemistry by Jerold Chun, Timothy Hla, Sarah Spiegel, Wouter Moolenaar

By Jerold Chun, Timothy Hla, Sarah Spiegel, Wouter Moolenaar

The present country of the technology helping new examine in lysophospholipids

The examine of lysophospholipids exploded with the invention of cellphone floor receptors on either lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). considering then, hundreds of thousands of unique study reports—ranging from primary mobilephone signaling to the body structure and pathophysiology of person organ systems—have situated on lysophospholipids. This booklet attracts jointly and analyzes the present literature to supply readers with a state-of-the-science evaluation in addition to present options that help examine in all points of the sphere of lysophospholipid signaling.

Lysophospholipid Receptors is split into 3 sections:

  • Receptors and different attainable effectors
  • Enzymes
  • Physiology and pathophysiology

Within each one part, the authors clarify the similarities and adjustments among LPA and S1P signaling. Examples are only if show the underlying mechanisms of lysophospholipid signaling throughout a vast variety of organ platforms, comparable to S1P signaling in cardiovascular body structure and illness and the neural results of LPA signaling. huge references on the finish of every bankruptcy offer a gateway to the literature and facilitate extra study into person topics.

Each bankruptcy has been authored by way of a number of top overseas professionals in lysophospholipid examine. according to a radical research of the present examine, the authors set forth what's verified technology and supply their professional opinion and viewpoint on new and rising parts of study, environment the degree for additional investigations that may remedy present difficulties within the field.

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Extra resources for Lysophospholipid Receptors: Signaling and Biochemistry

Sample text

Nat Cell Biol 5:38–45. 137. Fukushima N, Weiner JA, Kaushal D, Contos JJ, Rehen SK, Kingsbury MA, et al. 2002. Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons. Mol Cell Neurosci 20:271–282. 138. Fukushima N, Kimura Y, Chun J. 1998. A single receptor encoded by vzg-1/lpA1/ edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc Natl Acad Sci U S A 95:6151–6156. 139. Svetlov SI, Ignatova TN, Wang KK, Hayes RL, English D, Kukekov VG.

47. Bollen M, Gijsbers R, Ceulemans H, Stalmans W, Stefan C. 2000. Nucleotide pyrophosphatases/phosphodiesterases on the move. Crit Rev Biochem Mol Biol 35:393–432. 48. Lee HY, Clair T, Mulvaney PT, Woodhouse EC, Aznavoorian S, Liotta LA, et al. 1996. Stimulation of tumor cell motility linked to phosphodiesterase catalytic site of autotaxin. J Biol Chem 271:24408–24412. 49. Hama K, Aoki J, Fukaya M, Kishi Y, Sakai T, Suzuki R, et al. 2004. Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.

Am J Physiol 214:337–341. 9. Tokumura A, Fukuzawa K, Tsukatani H. 1978. Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species. Lipids 13:572–574. 10. Blankley CJ, Kaplan HR. 1984. Biologically-active phospholipids as potential cardiovascular drugs. Drug Dev Res 4:351. 11. Porn MI, Akerman KE, Slotte JP. 1991. High-density lipoproteins induce a rapid and transient release of Ca2+ in cultured fibroblasts. Biochem J 279(Pt 1):29–33. 12. Gerrard JM, Kindom SE, Peterson DA, Peller J, Krantz KE, White JG.

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