By Lawrence J., M.D. Albers, Rhoda Hahn, Christopher, M.D. Reist
This compact guide gains dosage, facet influence, and drug interplay details for all psychiatric medicines. It comprises details that's important to the psychiatrist, internist, and pupil.
Read Online or Download Handbook of Psychiatric Drugs, 2004 Edition (Current Clinical Strategies) PDF
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Extra resources for Handbook of Psychiatric Drugs, 2004 Edition (Current Clinical Strategies)
When phenytoin and carbamazepine are given at the same time, the levels of both drugs may be decreased. 3. Decreased ethosuximide levels due to cytochrome P450 enzyme induction. 4. Felbamate can decrease carbamazepine levels but increase the active metabolite, which has been implicated in toxicity. 5. Lamotrigine and valproate can increase the active metabolite. Patients may have signs of toxicity with normal carbamazepine levels. Carbamazepine will cause decreased valproate levels. D. Carbamazepine will induce hepatic microsomal enzymes and enhance the metabolism, decrease serum levels and decrease the effectiveness of the following medications: 1.
Prolonged use of benzodiazepines (generally greater than 3 weeks) is associated with tolerance, dependence and withdrawal syndromes. C. The choice of benzodiazepine hypnotic is usually dictated by the need for sleep onset or sleep maintenance, half-life, and drug interactions. IV. Adverse Drug Reactions A. Daytime sedation or morning “hangover” is a major complaint when patients take hypnotics with long half-lives. Dizziness and ataxia may occur during the daytime or if the patient awakens during the night.
Lamotrigine has efficacy in the treatment of bipolar depression as an adjunctive agent or as monotherapy. It has also been shown to decrease relapse to depression in stable bipolar patients by itself. Its efficacy in the treatment of bipolar mania or rapid cycling is not supported by current data. It is recommended that lamotrigine be used primarily as an adjunctive agent due to lack of proven efficacy in the treatment or prevention of mania. B. It is more effective in depression compared to other mood stabilizers, prompting use in treatmentresistant unipolar depression.