Chemical biology of glycoproteins by Zhongping Tan, Lai-Xi Wang (eds.)

By Zhongping Tan, Lai-Xi Wang (eds.)

Glycans play an essential function in modulating protein constitution and serve as from involvement in protein folding, solubility and balance to law of tissue distribution, acceptance specificity, and organic task. they could act as either confident and adverse regulators of protein functionality, supplying an extra point of keep an eye on with appreciate to genetic and environmental conditions.Due to the complexity of Read more...


This publication describes the advance and alertness of glycoprotein and glycan synthesis applied sciences as instruments for realizing and manipulating protein glycosylation. Read more...

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Protein glycosylation can be categorized into three major types: N-glycosylation, in which the sugar moiety is attached at the amide side chain of an Asn residue usually through a N-acetylglucosamine (GlcNAc)–Asn linkage; typical O-glycosylation, in which the sugar moiety is attached to the hydroxyl group of the Ser/Thr residues; and glypiation, where newly synthesized proteins are modified by covalent attachment of a glycosylphosphatidylinositol (GPI) anchor that helps Chemical Biology No. org 20 Chemical Biology of Protein N-Glycosylation 21 localize proteins to the cell membrane.

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