By Benjamin A. Lieberman
This quantity of the tools in Molecular Biology sequence is solely dedicated to the learn of steroid receptor biology. Steroid hormone receptors characterize a strong process for the examine of either the main basic molecular mec- nisms of gene legislation and regulate and the gross physiological responses of organisms to steroid hormones. examine during this box has introduced forth advances within the remedy of melanoma, endocrine problems, and reproductive biology, and allowed elucidation of the basic organic mechanisms of gene expr- sion. In Steroid Receptor tools: Protocols and Assays, the reader will discover a number of tools and protocols submitted through many high-quality steroid receptor researchers from during the international. those authors were advised to create a hugely informative cross-section of the newest study recommendations ava- capable. The ensuing paintings is well timed, priceless, and approachable for either the ex- rienced researcher and the amateur to the sphere. as the steroid receptor family members is represented by means of a superbly various, but strongly interrelated set of steroid receptor proteins, Steroid Receptor equipment includes protocols for the prod- tion and purification of a number of receptor kinds, together with the progesterone, glucocorticoid, and androgen receptors. those approaches give you the uncooked ma- rial had to behavior refined biochemical research of receptor homes. different recommendations awarded enable the reader to accomplish biochemical experiments on DNA binding features, hormone binding assays, and protocols utilizing combinatorial chemistry for drug discovery.