By P. Amarenco
Complement factor: Cerebrovascular ailments 2003, Vol. sixteen, Suppl. three
Read or Download Cardiovascular Risk Factor Management in the Prevention of Stroke: Satellite Symposium Held on the Occasion of the 11th European Stroke Conference, ... 2002: Proceedings (CEREBROVASCULAR DISEASES) PDF
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Extra resources for Cardiovascular Risk Factor Management in the Prevention of Stroke: Satellite Symposium Held on the Occasion of the 11th European Stroke Conference, ... 2002: Proceedings (CEREBROVASCULAR DISEASES)
Eur Neurol 1988;28:227–231. 10 Wolf PA, D’Agostino RB, O’Neal MA, Sytkowski P, Kase CS, Belanger AJ, Kannel WB: Secular trends in stroke incidence and mortality. The Framingham Study. Stroke 1992;23: 1551–1555. 11 Bronner LL, Kanter DS, Manson JE: Primary prevention of stroke. N Engl J Med 1995;333: 1392–1400. 12 Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party. BMJ 1992;304:405– 412. Stroke Prevention: A Note to Neurologists 13 Psaty BM, Smith NL, Siscovick DS, Koepsell TD, Weiss NS, Heckbert SR, Lemaitre RN, Wagner EH, Furberg CD: Health outcomes associated with antihypertensive therapies used as first-line agents.
The United Kingdom Transient Ischaemic Attack Collaborative Group. BMJ 1996; 313:147. 29 PROGRESS Collaborative Group: Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 2001;358:1033–1041. 30 Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE: Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997;96:1432–1437. 38 31 Lonn E, Yusuf S, Dzavik V, Doris C, Yi Q, Smith S, Moore-Cox A, Bosch J, Riley W, Teo K; SECURE Investigators: Effects of ramipril and vitamin E on atherosclerosis: the study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E (SECURE).
The SPARCL trial has enrolled approximately 4,600 patients and results are expected in 2004. The reasons for the benefits of statin therapy in stroke prevention are unclear since, paradoxically, the link between serum cholesterol level and stroke has never been fully established. Furthermore, the positive results of statins trials were mainly obtained in patients with an average or low serum cholesterol level. This suggests nonhyperlipidaemic effects of these drugs, which promote atherosclerotic plaque stability, may also play a role.