Cardiovascular Magnetic Resonance Spectroscopy by Gregory G. Schwartz, Michael W. Weiner (auth.), Saul

By Gregory G. Schwartz, Michael W. Weiner (auth.), Saul Schaefer M.D., Robert S. Balaban Ph.D. (eds.)

The program of magnetic resonance spectroscopy (MRS) to the cardiovascular procedure is a comparatively new phenomenon. Its skill to noninvasively research myocardial metabolism has resulted in its use to reply to simple questions in animal types of ordinary and diseased myocardium. Extension of those investigations into the world of human myocardial metabolism has been made attainable through the appearance of particularly high-field magnets with spectroscopy functions and adequate bore dimensions to permit human reports. whereas ongoing and destiny experiences promise to reinforce our figuring out of myocardial metabolism, their good fortune will, partly, depend upon an intensive knowing of the technical and biologic elements of cardiovascular MRS, in addition to the present kingdom of analysis within the many parts encompassed through this self-discipline.
it's with idea that the current monograph has been written. The association and content material should still lend this booklet to either the start reader who's yet no longer accustomed to cardiovascular MRS, in addition to to the lively investigator who needs to consult a quantity that bargains with the various problems with this box in a concise yet whole demeanour. The monograph is established with a common evaluate of the sphere, by way of a piece addressing the technical problems with cardiovascular MRS. the following part is dedicated to biologic problems with either basic and irregular myocardial metabolism, essentially dedicated to investigations making use of phosphorus-31. this is often by means of a bit facing extra really expert concerns, more often than not concerning different nuclei similar to protons, carbon, and sodium. eventually, the scientific functions of cardiovascular MRS are addressed.

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That is inherently orthogonal to the circular coil, so the coils are substantially electrically isolated; it can even be used for IH decoupling or Overhauser enhancement [36}. A PRACTICAL CARDIAC COIL SET A prototype cardiac NMR coil set based on the above philosophy is pictured in figure 3-6. 5, and 8 cm, and a single-turn 8-cm X 13-cm figure-8 1 H receiver coil, both made of 3-mm copper pipe [2, 36, 33}' The two receiver coils are fixed relative to each other in a robust coil former, with the 31p coil on top, but they can be moved off-center relative to the transmitter coil via "velcro" attachments.

On axis, the decrease in field with depth y is proportional to (a 2 + l) - 512, where a is the surface-coil radius from which the compensation can be calculated. However, varying the pulse power is an unsatis- ,1 3. IN VIVO HUMAN CARDIAC PHOSPHORUS NMR SPECTROSCOPY 35 FIGURE 3-6. Photograph of a practical coplanar three-coil set for cardiac spectroscopy comprising a large 40cm-square 3 1P transmitter coil, and smaller 8 X 13-cm figure-8-shaped I Hand 6. 31 P receiver coils (center), attached to the transmitter coil former via velcro strips.

Skeletal muscle metabolism in patients with congestive heart failure: relation to clinical severity and blood flow. Circulation 76:10091019. Bottomley PA (1986). A practical guide to getting NMR spectra In VIVO. In Medical Magnetic Resonance Imaging and Spectroscopy, a Primer. Berkeley: Society of Magnetic Resonance in Medicine, pp. 81-95. Edelstein WA, Glover GH, Hardy C), Redington R W (1986). The intrinsic signal-tonoise ratio in NMR imaging. Magn Reson Med 3:604-618. Bottomley PA, Hardy C) (1989).

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