Cardiovascular Disease in the Elderly by Samer S. Najjar MD, Edward G. Lakatta MD (auth.), Gary

By Samer S. Najjar MD, Edward G. Lakatta MD (auth.), Gary Gerstenblith MD (eds.)

As the quantity, availability, and sometimes the invasiveness and linked dangers of recent cardiovascular remedies expands, health and wellbeing care services are more and more known as upon to come to a decision even if to suggest those treatments to the expanding numbers of older sufferers with heart problems. In heart problems within the aged, a panel of clinicians, researchers, and leaders within the box evaluation and speak about the newest findings at the pathophysiology, analysis, and administration of heart problems within the older sufferer. The authors clarify the physiological adjustments linked to the traditional getting older technique which may bring about the advance of affliction, to adversarial results as soon as disorder develops, and which modify the risk-benefit equation for clinical and different interventions designed to diagnose, check, and deal with heart problems. the point of interest is on really universal syndromes within the aged, together with cardiac failure with common ejection fraction, remoted systolic high blood pressure, and atrial traumatic inflammation. at any place attainable, the authors take an evidence-based method of thoughts and depend seriously on potential scientific trials. the price of way of life alterations within the getting older inhabitants, using fundamental and secondary prevention options, and the therapy of acute and persistent ischemic illness and its issues also are mentioned.
accomplished and authoritative, heart problems within the aged deals physicians and different prone who deal with the older sufferer a gold-standard method of figuring out and handling heart problems during this group.

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The velocity of the pulse wave in vivo is determined not only by the intrinsic stress–strain relationship (stiffness) of the vascular wall, but also by smooth muscle tone, which is reflected by the mean arterial pressure (MAP) (53). Chapter 1 / Aging of the Heart and Arteries 27 The availability of noninvasive measures of the velocity of this pulse wave allows for large-scale epidemiological studies. Pulse wave velocity (PWV) was assessed in BLSA participants who were rigorously screened for the absence of overt or silent CVD (19) and in other populations with varying degrees of prevalence of CVD (23,49,54–57).

41. 42. 43. 44. 45. 46. Cardiovascular Disease in the Elderly tion resistance of lipoproteins, and atherosclerotic progression. Am J Cardiol 1995; 76:34C–39C. Hodis HN, Mack WJ, LaBree L, et al. Reduction in carotid arterial wall thickness using lovastatin and dietary therapy: a randomized controlled clinical trial. Ann Intern Med 1996;124:548–556. Markus RA, Mack WJ, Azen SP, Hodis HN. Influence of lifestyle modification on atherosclerotic progression determined by ultrasonographic change in the common carotid intima-media thickness.

Recent evidence suggests that the expression of growth factors is modulated by advanced glycosylation end products (136). Thus, the age-associated impairment in angiogenesis is, in part, owing to changes in the levels of extracellular enzymes, matrix proteins, and growth factors, which affect endothelial cell migration. An Integrated View of Vascular Aging An integrated and comprehensive conceptualization of arterial aging requires improved methods for studying endothelial function and an understanding of as yet unrecognized genetic and polymorphic components of arterial structure and function.

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