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Additional resources for Basal Ganglia - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Quantifying two types of postural and oromotor control in the same subjects will also substantially increase our understanding of the role of the basal ganglia in axial motor control. ; Professor; Biophysics; Medical College of Wisconsin Po Box26509 Milwaukee, Wi 532260509 Timing: Fiscal Year 2002; Project Start 01-JUL-1995; Project End 31-MAR-2003 Summary: The central theme of this Program Project competitive renewal proposal is the fundamental development of functional magnetic resonance imaging (fMRI) into a quantitative basis of mental health.
Physiology; University of California San Francisco 500 Parnassus Ave San Francisco, Ca 941222747 Timing: Fiscal Year 2003; Project Start 01-SEP-2003; Project End 31-OCT-2005 Summary: (provided by applicant): Vocal learning and control in songbirds, a system with many striking parallels to human speech, is used here as a model system to address general issues in the sensorimotor learning and control of complex behaviors. These issues include the production of sequences of stereotyped motor acts, the adaptive correction of errors in a motor plan, and the role of a basal ganglia circuit in adult motor Studies 35 control and plasticity.
It is hypothesized that adenosine A2A antagonists are acting on striatopallidal GABAergic neurons that also express DA D2 receptors. In view of research showing that haloperidol increases extracellular GABA in globus pallidus, and that haloperidol-induced tremulous jaw movements are reduced by pallidal injections of bicuculline, it is hypothesized that doses of adenosine A2A antagonists that reduce jaw movement activity also will reduce haloperidol-induced increases in GABA release in globus pallidus.