By Hyman M., Ed. Schipper
256 pages, sixty seven figures, 6 tables, hardcover This monograph is the 1st of its type to concentration in particular at the position of astroglia in aging-related human neurodegenerative issues and experimental types of CNS senescence and degeneration. As such, this quantity within the Neuroscience Intelligence Unit sequence represents a unique and demanding contribution to the fundamental and scientific neuroscience literature. The chapters are grouped into 3 sections: I. Biology of Astrocytes. The chapters during this part will represent a accomplished dialogue of the recognized services of astroglia within the mammalian CNS and the jobs those cells may perhaps play within the pathophysiology of neurological issues. II. Astrocytes in Human mind Senescence and Neurodegenerative problems. during this part, the pathology of astrocytes and their putative roles in human CNS senescence and diverse neurodegenerative stipulations are lined in significant aspect. III. Experimental types of Astrocyte Senescence: Implications for Neurodegenerative ! disorder. during this ultimate part, experimental techniques to the delineation of the function of astroglia in mind getting older and degeneration are defined. This e-book may still attraction largely to simple neuroscientists drawn to a variety of points of the biology of those cells in addition to to clinically-oriented investigators keen on the pathogenesis of the main human neurodegenerative issues.
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Additional info for Astrocytes in Brain Aging and Neurodegeneration (Neuroscience Intelligence Unit 3)
Janigro D, Gasparini S, D’Ambrosio R et al. Reduction of K+ uptake in glia prevents longterm depression maintenance and causes epileptiform activity. J Neurosci 1997; 17:2813-2824. 22. Krnjevic K, Schwartz S. Some properties of unresponsive cells in the cerebral cortex. Exp Brain Res 1967; 3:306-319. 23. Bevan S, Chiu SY, Gray PTA et al. Presence of voltage-gated sodium, potassium and chloride channels in rat cultured astrocytes. Phil Trans Roy Soc of London: Biol 1985; 225:299-313. 24. Bowman CL, Kimelberg HK, Frangakis MV et al.
5HT1A,114 mGluR5,115 mGluR3,116 AMPA receptor subunits GluR1 and GluR4117 and muscarinic receptor118 immunoreactivities have also been localized to astrocytes in rat hippocampus. Paspalas and Papadopoulos119 have recently reported that fine norepinephrine-containing nerve terminals ended on astrocytes around capillaries in rat visual cortex, as well as directly on the basal lamina. However, no plasma membrane differentiation at these sites on the astrocyte membranes was detected. In situ hybridization is now beginning to be used to localize receptor mRNA in astrocytes in intact brain.
J Neurosci 1989; 9:2011-2019. 58. Grichtchenko II, Chesler M. Depolarization-induced alkalinization of astrocytes in gliotic hippocampal slices. Neurosci 1994; 62:1071-1078. 59. Kimelberg HK. Astrocytic edema in CNS trauma. 1:S71-S81. 60. Kempski O, Zimmer M, Neu A et al. Control of glial cell volume in anoxia in vitro studies on ischemic cell swelling. Stroke 1987; 18:623-628. 61. Balazs R, Patel AJ, Richter D. Metabolic Compartmentation in the Brain. London: MacMillan Press, 1973:167-184. 62.