Alcohol and Cardiovascular Disease - Symposium No. 216 by Novartis Foundation

By Novartis Foundation

Either well timed and topical, this e-book examines an important facets of the connection among alcohol intake and future health. Drawing jointly a lot new and interesting paintings during this region, it stories this emotive topic from a dispassionate viewpoint. it is going to offer a company base for extra learn into the consequences of alcohol at the cardiovascular process, and into public wellbeing and fitness attitudes to what's either a common excitement and challenge.

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Example text

This was not true, interestingly, for fasting glucose. It is quite a marked effect. There is some evidence from epidemiological studies that individuals who have insulin resistance may particularly benefit from the effects of moderate alcohol consumption in terms of the incidence of cardiovascular disease. Urbana-Mdrqt/e~: With regard to the effect of alcohol on insulin resistance, in our experience heavy drinkers have insulin values higher than controls. But interestingly, after one month of stopping drinking their insulin values are similar to controls.

Goode Copyright 0 1998 by Novartis Foundation Alcohol and the myocardium P. J. Richardson, V. B. Patel* and V. R. Preedy* Molecular and Metabolic Cardiology Group, Departments of Cardiology and *Clinical Biochemistry, King’s College School of Medicine and Dentistry, Bessemer Road, London SE59PJ, UK A bstratt. Structural and functional abnormalities are prominent in alcoholic cardiomyopathy (ACM). Histological features in affected subjects are almost identical to the characteristics of dilated cardiomyopathy.

If you hypothesize that acetaldehyde is a major mediator of the deleterious effects of alcohol, you would have to also assume that those people who have a defect in acetaldehyde metabolism should develop a higher incidence of these effects. Peters: There is some evidence that the heterozygotes are more likely to develop alcoholic liver disease at lower net alcohol doses than western-type homozygotes. There are also certain individuals who potentiate the effect of alcohol by taking small amounts of disulfiram.

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