By David Y. Hwang
50 reports each Neurologist should still Know provides key reports that form the present scientific perform of neurology. All neurologic subspecialties are coated, with a unique emphasis on neurocritical care and vascular neurology. for every research, a concise precis is gifted with an emphasis at the effects and boundaries of the examine, and its implications for perform. An illustrative medical case concludes every one evaluation, through short details on different correct reviews. this is often the 1st e-book of its style to give a set of the main influential scientific trials in neurology which are particular adequate for use on rounds, yet nonetheless simply digestible. it's a must-read for overall healthiness care execs and a person who desires to study extra in regards to the facts at the back of scientific practice.
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Extra info for 50 Studies Every Neurologist Should Know (Fifty Studies Every Doctor Should Know)
2007;68:402–4 08. 4. Saetre E et al. An international multicenter randomized double-blind controlled trial of lamotrigine and sustained-release carbamazepine in the treatment of newly diagnosed epilepsy in the elderly. Epilepsia. 2007;48:1292–1302. 5. Glauser T et al. ILAE treatment guidelines: Evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures. Epilepsia. 2006;47(7):1094–1120. 6. Brodie MJ et al. Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy.
2. 02 Values are least squares mean scores. LOCF = last observation carried forward. c SIB range of possible scores: 0–100. Higher score indicates better function. d ADCS-ADL19 range of possible scores: 0–54. Higher score indicates better function. a b Criticisms and Limitations: The results of the trial are restricted to patients with MMSE scores of 5–14. 8 While using the Ischemic Score to exclude patients with vascular dementia, it may have included patients with non-AD dementias. 10 A high11 percentage of patients discontinued study participation (fully a fourth of the placebo group, 51/201; and 30/203 assigned to receive memantine), which may have introduced inaccuracies in findings.
Curr Alzheimer Res. 2008;5(1):83–89. 19. At a dose of 28 mg daily, rather than 10 mg twice daily used in the trial in Tariot et al. In addition, no increase in confusion was seen in the memantine group; Grossberg et al. ) 21. Especially since the absolute benefit of the addition of memantine is small, the population with dementia is already at higher risk for delirium (and the study in Tariot et al. ), and, when possible, polypharmacy in the elderly should be avoided. Memantine for Alzheimer’s Disease 1 SECTION II Epilepsy 3 Lorazepam for Generalized Status Epilepticus P U E FA R O O Q U E Although lorazepam was no more efficacious than phenobarbital or than diazepam and phenytoin, it is easier to use.